CACNA2D2 - Voltage-dependent calcium channel subunit alpha-2/delta-2 - human protein (Function)
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CACNA2D2 »  Voltage-dependent calcium channel subunit alpha-2/delta-2
Protein also known as:  Voltage-gated calcium channel subunit alpha-2/delta-2. Cleaved into:  Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2.
Gene name:  CACNA2D2
Entry whose protein(s) existence is based on evidence at protein level
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The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(2+) channel auxiliary subunit 2 types 1-4 (cca-2) family  8.A.18.2.1  
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Voltage-gated calcium channel activitydefinition[GO:0005245] silver  
  • IEAOrtholog Compara
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588]  
  • IEAUniProtKB KW
Muscle fiber developmentdefinition[GO:0048747] silver  
  • IEAOrtholog Compara
Neuromuscular junction developmentdefinition[GO:0007528] silver  
  • IEAOrtholog Compara
Positive regulation of organ growthdefinition[GO:0046622] silver  
  • IEAOrtholog Compara
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Regulation of multicellular organism growthdefinition[GO:0040014] silver  
  • IEAOrtholog Compara
Rhythmic synaptic transmissiondefinition[GO:0060024] silver  
  • IEAOrtholog Compara
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+9254  
Cardiac muscle contraction  hsa04260+9254  
Dilated cardiomyopathy  hsa05414+9254  
Hypertrophic cardiomyopathy (HCM)  hsa05410+9254  
MAPK signaling pathway  hsa04010+9254  
According to Reactome, this protein belongs to the following pathways:
Adrenaline,noradrenaline inhibits insulin secretion  REACT_18339  
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels  REACT_13606  
Regulation of insulin secretion  REACT_18325  


Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: CACNA2D2
GenomeRNAi: 9254