AATF - Protein AATF - human protein (Function)
 
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AATF »  Protein AATF
 
Protein also known as:  Apoptosis-antagonizing transcription factor.
Gene name:  AATF
Family name: AATF
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.  
4
  • CuratedUniProtKB
GO molecular function 
Leucine zipper domain bindingdefinition[GO:0043522]  
2
  • IPIUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAUniProtKB
Tau protein bindingdefinition[GO:0048156] silver  
  • IEAOrtholog Compara
GO biological process 
Cell adhesiondefinition[GO:0007155] silver  
  • IEAOrtholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IEPUniProtKB
Embryonic cleavagedefinition[GO:0040016] silver  
  • IEAOrtholog Compara
Negative regulation of amyloid precursor protein biosynthetic processdefinition[GO:0042985] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IMPUniProtKB
Negative regulation of reactive oxygen species metabolic processdefinition[GO:2000378]  
1
  • IDAUniProtKB
Negative regulation of superoxide anion generationdefinition[GO:0032929]  
1
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Regulation of mitotic cell cycledefinition[GO:0007346] silver  
  • IEAOrtholog Compara
Ribosome biogenesisdefinition[GO:0042254] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
NRAGE signals death through JNK  REACT_13638  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links