B3GNT2 - N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 - human protein (Function)
 
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Protein
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References

 
B3GNT2 »  N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2   [ EC 2.4.1.149 ]
 
Protein also known as:  UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7.
Gene name:  B3GNT2
Family name: Glycosyltransferase 31
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed9892646). Probably constitutes the main polylactosamine synthase.  
4
  • UniProtKB
GO molecular function 
Galactosyltransferase activitydefinition[GO:0008378] silver  
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  • InterPro 2 GO
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activitydefinition[GO:0008532]  
3
  • UniProtKB
GO biological process 
Axon guidancedefinition[GO:0007411] silver  
1
  • Ortholog Compara
Poly-N-acetyllactosamine biosynthetic processdefinition[GO:0030311]  
3
  • UniProtKB
Sensory perception of smelldefinition[GO:0007608] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.149: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R.  
4
  • UniProtKB
It requires the following cofactor
 Mn(2+)  
2
  • UniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 31  GT31  
Pathways 
This protein is involved in the following pathway
Protein modification; protein glycosylation  
2
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Glycosaminoglycan biosynthesis - keratan sulfate  hsa00533+10678  
Glycosphingolipid biosynthesis - lacto and neolacto series  hsa00601+10678  
Metabolic pathways  hsa01100+10678  
According to Reactome, this protein belongs to the following pathways:
Keratan sulfate biosynthesis  REACT_121120  
O-linked glycosylation of mucins  REACT_115606  
Caution 
Was indicated as B3Gal-T6 in submitted DNA entries.  
1
  • UniProtKB
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: B3GNT2
GenomeRNAi: 10678
PRO: PR:Q9NY97