ABI2 - Abl interactor 2 - human protein (Function)
 
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Protein
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ABI2 »  Abl interactor 2
 
Protein also known as:  Abl-binding protein 3 (AblBP3).
Gene name:  ABI2
Family name: ABI
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 36 4
GENE REF ISO

Function

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Overview 
May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.  
4
  • UniProtKB
GO molecular function 
Cytoskeletal adaptor activitydefinition[GO:0008093]  
1
  • UniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • PINC
Kinase bindingdefinition[GO:0019900]  
1
  • UniProtKB
Proline-rich region bindingdefinition[GO:0070064]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein complex bindingdefinition[GO:0032403]  
1
  • UniProtKB
Contributes to Rac GTPase bindingdefinition[GO:0048365]  
1
  • UniProtKB
SH3 domain bindingdefinition[GO:0017124]  
2
  • UniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • BHF-UCL
GO biological process 
Actin polymerization or depolymerizationdefinition[GO:0008154]  
1
  • UniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • UniProtKB
Cellular component movementdefinition[GO:0006928]  
1
  • UniProtKB
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • UniProtKB
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • MGI
Positive regulation of Arp2/3 complex-mediated actin nucleationdefinition[GO:2000601]  
1
  • UniProtKB
Rac protein signal transductiondefinition[GO:0016601]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Regulation of actin cytoskeleton  hsa04810+10152  
According to Reactome, this protein belongs to the following pathways:
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
VEGFA-VEGFR2 Pathway  REACT_228166  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABI2
GenomeRNAi: 10152
PRO: PR:Q9NYB9