KCNK4 - Potassium channel subfamily K member 4 - human protein (Function)
 
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Protein
Gene
References

 
KCNK4 »  Potassium channel subfamily K member 4
 
Protein also known as:  TWIK-related arachidonic acid-stimulated potassium channel protein (TRAAK).
Gene name:  KCNK4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 16 2
GENE REF ISO

Function

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Overview 
Voltage-insensitive potassium channel (PubMed22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed22282805, PubMed25471887, PubMed25500157). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).  
6
  • UniProtKB
GO molecular function 
Mechanically-gated potassium channel activitydefinition[GO:0098782]  
1
  • UniProtKB
Potassium channel activitydefinition[GO:0005267]  
1
  • UniProtKB
Potassium ion leak channel activitydefinition[GO:0022841]  
1
  • RefGenome
Temperature-gated cation channel activitydefinition[GO:0097604]  
1
  • Ortholog Curator
Voltage-gated ion channel activitydefinition[GO:0005244]  
1
  • UniProtKB KW
GO biological process 
Cellular response to alkaline pHdefinition[GO:0071469]  
1
  • Ortholog Curator
Cellular response to fatty aciddefinition[GO:0071398]  
1
  • UniProtKB
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • UniProtKB
Cellular response to temperature stimulusdefinition[GO:0071502]  
1
  • Ortholog Curator
Detection of mechanical stimulus involved in sensory perception of touchdefinition[GO:0050976]  
1
  • Ortholog Curator
Potassium ion transmembrane transportdefinition[GO:0071805]  
2
  • UniProtKB
  • RefGenome
Potassium ion transportdefinition[GO:0006813]  
1
  • PINC
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Sensory perception of paindefinition[GO:0019233]  
1
  • Ortholog Curator
Sensory perception of temperature stimulusdefinition[GO:0050951]  
1
  • Ortholog Curator
Stabilization of membrane potentialdefinition[GO:0030322]  
1
  • RefGenome
Enzymatic activity 
It is regulated in the following manner
Activated by arachidonic acid.  
3
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
TWIK related potassium channel (TREK)  REACT_75819  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNK4
GenomeRNAi: 50801
PRO: PR:Q9NYG8
Chemistry
GuidetoPHARMACOLOGY: 516