ZAK - Mitogen-activated protein kinase kinase kinase MLT - human protein (Function)
 
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ZAK »  Mitogen-activated protein kinase kinase kinase MLT
 
Gene name:  ZAK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 52 3
GENE REF ISO

Function

 show evidences
Overview 
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2.  
6
  • CuratedUniProtKB
Isoform  Iso 1   But not isoform 2, phosphorylates histone H3 at 'Ser-28'.  
6
  • CuratedUniProtKB
Isoform  Iso 1   But not isoform 2, causes cell shrinkage and disruption of actin stress fibers.  
6
  • CuratedUniProtKB
Isoform  Iso 1   May have role in neoplastic cell transformation and cancer development.  
6
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
MAP kinase kinase kinase activitydefinition[GO:0004709]  
1
  • IDAUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
GO biological process 
Activation of JUN kinase activitydefinition[GO:0007257]  
1
  • IDAUniProtKB
Activation of MAPKK activitydefinition[GO:0000186]  
1
  • TASUniProtKB
Cell cycle arrestdefinition[GO:0007050]  
1
  • IMPUniProtKB
Cell cycle checkpointdefinition[GO:0000075]  
1
  • IDAUniProtKB
Cell deathdefinition[GO:0008219]  
1
  • NASUniProtKB
Cell differentiationdefinition[GO:0030154]  
1
  • NASUniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • NASUniProtKB
Cytoskeleton organizationdefinition[GO:0007010] silver  
  • IEAOrtholog Compara
DNA damage checkpointdefinition[GO:0000077]  
1
  • IMPUniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAUniProtKB
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Response to radiationdefinition[GO:0009314]  
1
  • IDAUniProtKB
Response to stressdefinition[GO:0006950]  
1
  • NASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.25: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphorylation by PKN1 and autophosphorylation on Thr-161 and Ser-165.  
3
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
MAPK signaling pathway  hsa04010+51776  
Tight junction  hsa04530+51776  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ZAK
GenomeRNAi: 51776
PRO: PR:Q9NYL2
Chemistry
GuidetoPHARMACOLOGY: 2289