CYP39A1 - 24-hydroxycholesterol 7-alpha-hydroxylase - human protein (Function)
 
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CYP39A1 »  24-hydroxycholesterol 7-alpha-hydroxylase   [ EC 1.14.13.99 ]
 
Protein also known as:  Oxysterol 7-alpha-hydroxylase.
Gene name:  CYP39A1
Family name: Cytochrome P450
Entry whose protein(s) existence is based on evidence at transcript level
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1 13 1
GENE REF ISO

Function

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Overview 
Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha-hydroxylated product.  
  • CuratedUniProtKB
GO molecular function 
24-hydroxycholesterol 7alpha-hydroxylase activitydefinition[GO:0033782]  
  • IEAEC 2 GO
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
Oxysterol 7-alpha-hydroxylase activitydefinition[GO:0008396]  
1
  • IDAUniProtKB
Steroid 7-alpha-hydroxylase activitydefinition[GO:0008387] silver  
  • IEAOrtholog Compara
GO biological process 
Bile acid biosynthetic processdefinition[GO:0006699]  
1
  • IDAUniProtKB
Bile acid catabolic processdefinition[GO:0030573]  
  • IEAUniProtKB KW
Cholesterol catabolic processdefinition[GO:0006707] silver  
  • IEAOrtholog Compara
Digestiondefinition[GO:0007586]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.14.13.99: (24R)-cholest-5-ene-3-beta,24-diol + NADPH + O(2) (24R)-cholest-5-ene-3-beta,7-alpha,24-triol + NADP(+) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Heme group (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Primary bile acid biosynthesis  hsa00120+51302  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Bile acid catabolism  definition   [KW-0088]
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Steroid metabolism  definition   [KW-0753]
Molecular function 
Monooxygenase  definition   [KW-0503]
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CYP39A1
GenomeRNAi: 51302
PRO: PR:Q9NYL5