CDK12 - Cyclin-dependent kinase 12 - human protein (Function)
 
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CDK12 »  Cyclin-dependent kinase 12   [ EC 2.7.11.22EC 2.7.11.23 ]
 
Protein also known as:  Cell division cycle 2-related protein kinase 7 (CDC2-related protein kinase 7).
Gene name:  CDK12
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Cyclin bindingdefinition[GO:0030332]  
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  • IPIMGI
Cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0004693]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
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  • IPIUniProtKB
Protein kinase activitydefinition[GO:0004672]  
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  • IDAHGNC
RNA polymerase II carboxy-terminal domain kinase activitydefinition[GO:0008353]  
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  • IMPUniProtKB
GO biological process 
mRNA processingdefinition[GO:0006397]  
  • IEAUniProtKB KW
Phosphorylation of RNA polymerase II C-terminal domaindefinition[GO:0070816]  
1
  • IMPUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAHGNC
Regulation of cell cycledefinition[GO:0051726]  
  • IEAEC 2 GO
Regulation of MAP kinase activitydefinition[GO:0043405]  
1
  • IMPUniProtKB
RNA splicingdefinition[GO:0008380]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.7.11.23: ATP + [DNA-directed RNA polymerase] ADP + [DNA-directed RNA polymerase] phosphate.  
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  • CuratedUniProtKB
EC 2.7.11.22: ATP + a protein ADP + a phosphoprotein.  
2
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by the ATP analog flavopiridol, purvalanol A, purvalanol B, staurosporine and CR8.  
1
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
mRNA processing  definition   [KW-0507]
mRNA splicing  definition   [KW-0508]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CRKRS
GenomeRNAi: 51755
PRO: PR:Q9NYV4