TAS2R14 - Taste receptor type 2 member 14 - human protein (Function)
 
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Protein
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References

 
TAS2R14 »  Taste receptor type 2 member 14  (T2R14)
 
Protein also known as:  Taste receptor family B member 1 (TRB1).
Gene name:  TAS2R14
Entry whose protein(s) existence is based on evidence at protein level
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1 15 1
GENE REF ISO

Function

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Overview 
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Bitter taste receptor activitydefinition[GO:0033038]  
2
  • IDAUniProtKB
  • IDAHGNC
Taste receptor activitydefinition[GO:0008527]  
2
  • IDAHGNC
  • TASUniProtKB
GO biological process 
Detection of chemical stimulus involved in sensory perception of bitter tastedefinition[GO:0001580]  
2
  • IDAUniProtKB
  • IDAHGNC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • ICHGNC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Taste transduction  hsa04742+50840  
According to Reactome, this protein belongs to the following pathways:
Class C/3 (Metabotropic glutamate/pheromone receptors)  REACT_18319  
G alpha (i) signalling events  REACT_19231  
Note 
Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Taste  definition   [KW-0919]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TAS2R14
GenomeRNAi: 50840
PRO: PR:Q9NYV8