TAS2R13 - Taste receptor type 2 member 13 - human protein (Function)
 
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TAS2R13 »  Taste receptor type 2 member 13  (T2R13)
 
Protein also known as:  Taste receptor family B member 3 (TRB3).
Gene name:  TAS2R13
Entry whose protein(s) existence is based on evidence at protein level
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1 14 1
GENE REF ISO

Function

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Overview 
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.  
  • CuratedUniProtKB
GO molecular function 
Bitter taste receptor activitydefinition[GO:0033038]  
1
  • IDAUniProtKB
Taste receptor activitydefinition[GO:0008527]  
1
  • TASUniProtKB
GO biological process 
Detection of chemical stimulus involved in sensory perception of bitter tastedefinition[GO:0001580]  
1
  • IDAUniProtKB
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Positive regulation of cytokinesisdefinition[GO:0032467]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Taste transduction  hsa04742+50838  
According to Reactome, this protein belongs to the following pathways:
Class C/3 (Metabotropic glutamate/pheromone receptors)  REACT_18319  
G alpha (i) signalling events  REACT_19231  
Note 
Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Taste  definition   [KW-0919]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TAS2R13
GenomeRNAi: 50838
PRO: PR:Q9NYV9