TAS2R4 - Taste receptor type 2 member 4 - human protein (Function)
 
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Protein
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References

 
TAS2R4 »  Taste receptor type 2 member 4  (T2R4)
 
Gene name:  TAS2R4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency.  
1
  • CuratedUniProtKB
GO molecular function 
Taste receptor activitydefinition[GO:0008527]  
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  • TASUniProtKB
GO biological process 
Detection of chemical stimulus involved in sensory perception of tastedefinition[GO:0050912]  
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  • TASGOC
Respiratory gaseous exchangedefinition[GO:0007585] silver  
  • IEAOrtholog Compara
Sensory perception of tastedefinition[GO:0050909]  
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  • TASPINC
Signal transductiondefinition[GO:0007165]  
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  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Taste transduction  hsa04742+50832  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Note 
Several bitter taste receptors are expressed in a single taste receptor cell.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Sensory transduction  definition   [KW-0716]
Taste  definition   [KW-0919]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TAS2R4
GenomeRNAi: 50832
PRO: PR:Q9NYW5