ERAP1 - Endoplasmic reticulum aminopeptidase 1 - human protein (Function)
 
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ERAP1 »  Endoplasmic reticulum aminopeptidase 1   [ EC 3.4.11.- ]
 
Protein also known as:  Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator.
Gene name:  ERAP1
Family name: Peptidase M1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 79 2
GENE REF ISO

Function

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Overview 
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.  
3
  • CuratedUniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177]  
2
  • IDAUniProtKB
Interleukin-1, Type II receptor bindingdefinition[GO:0005151]  
1
  • TASHGNC
Interleukin-6 receptor bindingdefinition[GO:0005138]  
1
  • IPIUniProtKB
Metalloexopeptidase activitydefinition[GO:0008235]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • NASUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • TASHGNC
Antigen processing and presentation of endogenous peptide antigen via MHC class Idefinition[GO:0019885]  
2
  • TASHGNC
  • NASUniProtKB
Fat cell differentiationdefinition[GO:0045444]  
1
  • NASUniProtKB
Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
1
  • IDAUniProtKB
Positive regulation of angiogenesisdefinition[GO:0045766] silver  
  • IEAOrtholog Compara
Regulation of blood pressuredefinition[GO:0008217]  
2
  • TASHGNC
  • NASUniProtKB
Regulation of innate immune responsedefinition[GO:0045088]  
1
  • NASUniProtKB
Response to bacteriumdefinition[GO:0009617]  
1
  • IEPBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.11.-: Release of an N-terminal amino acid, Xaa-|-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Met, Cys and Phe.  
1
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Immunity  definition   [KW-0391]
Molecular function 
Aminopeptidase  definition   [KW-0031]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARTS-1
GenomeRNAi: 51752
PRO: PR:Q9NZ08