PSENEN - Gamma-secretase subunit PEN-2 - human protein (Function)
 
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Gene
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PSENEN »  Gamma-secretase subunit PEN-2
 
Protein also known as:  Presenilin enhancer protein 2.
Gene name:  PSENEN
Family name: PEN-2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.  
3
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
GO biological process 
Amyloid precursor protein catabolic processdefinition[GO:0042987]  
1
  • HGNC
Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
1
  • HGNC
Notch receptor processingdefinition[GO:0007220]  
1
  • HGNC
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • HGNC
Protein processingdefinition[GO:0016485]  
1
  • HGNC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+55851  
Notch signaling pathway  hsa04330+55851  
According to Reactome, this protein belongs to the following pathways:
Activated NOTCH1 Transmits Signal to the Nucleus  R-HSA-2122948  
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  R-HSA-2894862  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  R-HSA-2644606  
EPH-ephrin mediated repulsion of cells  R-HSA-3928665  
NOTCH2 Activation and Transmission of Signal to the Nucleus  R-HSA-2979096  
NRIF signals cell death from the nucleus  R-HSA-205043  
Nuclear signaling by ERBB4  R-HSA-1251985  
Regulated proteolysis of p75NTR  R-HSA-193692  
Signaling by NOTCH3  R-HSA-1980148  
Signaling by NOTCH4  R-HSA-1980150  
 

Keywords

Biological process 
Notch signaling pathway  definition   [KW-0914]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 55851
PRO: PR:Q9NZ42