PSENEN - Gamma-secretase subunit PEN-2 - human protein (Function)
 
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PSENEN »  Gamma-secretase subunit PEN-2
 
Gene name:  PSENEN
Family name: PEN-2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
Amyloid precursor protein catabolic processdefinition[GO:0042987]  
1
  • TASHGNC
Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
1
  • IDAHGNC
Notch receptor processingdefinition[GO:0007220]  
1
  • TASHGNC
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • IDAHGNC
Protein processingdefinition[GO:0016485]  
1
  • IDAHGNC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+55851  
Notch signaling pathway  hsa04330+55851  
According to Reactome, this protein belongs to the following pathways:
Activated NOTCH1 Transmits Signal to the Nucleus  REACT_118614  
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
NOTCH2 Activation and Transmission of Signal to the Nucleus  REACT_160205  
NRIF signals cell death from the nucleus  REACT_13643  
Nuclear signaling by ERBB4  REACT_116022  
Regulated proteolysis of p75NTR  REACT_13443  
Signaling by NOTCH3  REACT_118862  
Signaling by NOTCH4  REACT_118636  
 

Keywords

Biological process 
Notch signaling pathway  definition   [KW-0914]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 55851
PRO: PR:Q9NZ42