SMARCAL1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 - human protein (Function)
 
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Protein
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SMARCAL1 »  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1   [ EC 3.6.4.- ]
 
Protein also known as:  Sucrose nonfermenting protein 2-like 1.
Gene name:  SMARCAL1
Family name: SNF2/RAD54 helicase » SMARCAL1
Entry whose protein(s) existence is based on evidence at protein level
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1 52 1
GENE REF ISO

Function

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Overview 
ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.  
3
  • CuratedUniProtKB
GO molecular function 
Annealing helicase activitydefinition[GO:0036310]  
2
  • IDAUniProtKB
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
DNA bindingdefinition[GO:0003677] silver  
  • IEAInterPro 2 GO
DNA-dependent ATPase activitydefinition[GO:0008094]  
1
  • IMPUniProtKB
Helicase activitydefinition[GO:0004386]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • IMPGOC
  • IEAOrtholog Compara
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IMPUniProtKB
Chromatin modificationdefinition[GO:0016568] silver  
  • IEAInterPro 2 GO
DNA metabolic processdefinition[GO:0006259]  
1
  • IMPUniProtKB
DNA strand renaturationdefinition[GO:0000733]  
2
  • IDAGOC
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • IMPUniProtKB
Replication fork processingdefinition[GO:0031297]  
1
  • IMPUniProtKB
 

Keywords

Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SMARCAL1
GenomeRNAi: 50485
PRO: PR:Q9NZC9