SMARCAL1 - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 - human protein (Function)
 
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SMARCAL1 »  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1   [ EC 3.6.4.- ]
 
Protein also known as:  Sucrose nonfermenting protein 2-like 1.
Gene name:  SMARCAL1
Family name: SNF2/RAD54 helicase » SMARCAL1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 61 1
GENE REF ISO

Function

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Overview 
ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.  
4
  • UniProtKB
GO molecular function 
Annealing helicase activitydefinition[GO:0036310]  
2
  • UniProtKB
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
DNA bindingdefinition[GO:0003677] silver  
1
  • InterPro 2 GO
DNA-dependent ATPase activitydefinition[GO:0008094]  
1
  • UniProtKB
Helicase activitydefinition[GO:0004386]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
GO biological process 
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • UniProtKB
Chromatin modificationdefinition[GO:0016568] silver  
1
  • InterPro 2 GO
DNA metabolic processdefinition[GO:0006259]  
1
  • UniProtKB
DNA repairdefinition[GO:0006281] silver  
1
  • InterPro 2 GO
DNA strand renaturationdefinition[GO:0000733]  
3
  • GOC
  • InterPro 2 GO
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • UniProtKB
Replication fork processingdefinition[GO:0031297]  
1
  • UniProtKB
 

Keywords

Molecular function 
Helicase  definition   [KW-0347]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SMARCAL1
GenomeRNAi: 50485
PRO: PR:Q9NZC9