GRHL1 - Grainyhead-like protein 1 homolog - human protein (Function)
 
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Protein
Gene
References

 
GRHL1 »  Grainyhead-like protein 1 homolog
 
Protein also known as:  Transcription factor CP2-like 2.
Gene name:  GRHL1
Family name: Grh/CP2 » Grainyhead
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 18 3
GENE REF ISO

Function

 show evidences
Overview 
Transcription factor.  
1
  • UniProtKB
Isoform  Iso 1   May function as an activator and isoform 2 as a repressor in tissues where both forms are expressed. May play a role in development. May be involved in epidermal differentiation (By similarity). Binds and transactivates the EN1 promoter.  
2
  • UniProtKB
GO molecular function 
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • NTNU_SB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • RefGenome
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • RefGenome
GO biological process 
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • UniProtKB KW
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • NTNU_SB
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • RefGenome
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
PPARA activates gene expression  REACT_116145  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 29841
PRO: PR:Q9NZI5