GRHL1 - Grainyhead-like protein 1 homolog - human protein (Function)
 
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Protein
Gene
References

 
GRHL1 »  Grainyhead-like protein 1 homolog
 
Protein also known as:  Transcription factor CP2-like 2.
Gene name:  GRHL1
Family name: Grh/CP2 » Grainyhead
Entry whose protein(s) existence is based on evidence at protein level
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1 21 3
GENE REF ISO

Function

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Overview 
Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed12175488, PubMed18288204). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity).  
3
  • UniProtKB
Isoform  Iso 1   May function as an activator and isoform 2 as a repressor in tissues where both forms are expressed (PubMed12175488).  
4
  • UniProtKB
GO molecular function 
Chromatin DNA bindingdefinition[GO:0031490]  
1
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • NTNU_SB
Sequence-specific DNA bindingdefinition[GO:0043565]  
2
  • UniProtKB
  • RefGenome
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • RefGenome
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • UniProtKB
GO biological process 
Epidermis developmentdefinition[GO:0008544]  
1
  • Ortholog Curator
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • UniProtKB KW
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • NTNU_SB
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • RefGenome
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
PPARA activates gene expression  REACT_116145  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 29841
PRO: PR:Q9NZI5