EIF2AK3 - Eukaryotic translation initiation factor 2-alpha kinase 3 - human protein (Function)
 
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EIF2AK3 »  Eukaryotic translation initiation factor 2-alpha kinase 3   [ EC 2.7.11.1 ]
 
Protein also known as:  PRKR-like endoplasmic reticulum kinase.
Gene name:  EIF2AK3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Eukaryotic translation initiation factor 2alpha kinase activitydefinition[GO:0004694]  
4
  • IMPUniProtKB
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • ISSOrtholog Curator
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
  • ISSOrtholog Curator
Bone mineralizationdefinition[GO:0030282]  
  • ISSOrtholog Curator
Calcium-mediated signalingdefinition[GO:0019722]  
  • ISSOrtholog Curator
Chondrocyte developmentdefinition[GO:0002063]  
  • ISSOrtholog Curator
Endocrine pancreas developmentdefinition[GO:0031018]  
1
  • IMPUniProtKB
Endoplasmic reticulum organizationdefinition[GO:0007029]  
  • ISSOrtholog Curator
Endoplasmic reticulum unfolded protein responsedefinition[GO:0030968]  
4
  • IDAUniProtKB
  • TASBHF-UCL
ER overload responsedefinition[GO:0006983]  
2
  • IDAUniProtKB
Fat cell differentiationdefinition[GO:0045444] silver  
  • IEAOrtholog Compara
Insulin secretiondefinition[GO:0030073]  
  • ISSOrtholog Curator
Insulin-like growth factor receptor signaling pathwaydefinition[GO:0048009]  
  • ISSOrtholog Curator
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressdefinition[GO:0070059] silver  
  • IEAOrtholog Compara
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Negative regulation of myelinationdefinition[GO:0031642]  
  • ISSOrtholog Curator
Negative regulation of translationdefinition[GO:0017148]  
1
  • TASUniProtKB
Negative regulation of translational initiation in response to stressdefinition[GO:0032057]  
3
  • TASBHF-UCL
  • TASUniProtKB
Ossificationdefinition[GO:0001503]  
1
  • IMPUniProtKB
Positive regulation of protein bindingdefinition[GO:0032092] silver  
  • IEAOrtholog Compara
Positive regulation of signal transductiondefinition[GO:0009967] silver  
  • IEAOrtholog Compara
Protein autophosphorylationdefinition[GO:0046777]  
3
  • IMPUniProtKB
Protein homooligomerizationdefinition[GO:0051260]  
1
  • IMPUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
  • ISSOrtholog Curator
Regulation of fatty acid metabolic processdefinition[GO:0019217] silver  
  • IEAOrtholog Compara
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
1
  • IMPBHF-UCL
Skeletal system developmentdefinition[GO:0001501]  
  • ISSOrtholog Curator
SREBP signaling pathwaydefinition[GO:0032933] silver  
  • IEAOrtholog Compara
Translationdefinition[GO:0006412] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization, resulting in transautophosphorylation and kinase activity induction (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+9451  
Hepatitis C  hsa05160+9451  
Herpes simplex infection  hsa05168+9451  
Influenza A  hsa05164+9451  
Measles  hsa05162+9451  
Protein processing in endoplasmic reticulum  hsa04141+9451  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Stress response  definition   [KW-0346]
Translation regulation  definition   [KW-0810]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EIF2AK3
GenomeRNAi: 9451
PRO: PR:Q9NZJ5
Chemistry
GuidetoPHARMACOLOGY: 2017