ARHGEF12 - Rho guanine nucleotide exchange factor 12 - human protein (Function)
 
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Protein
Gene
References

 
ARHGEF12 »  Rho guanine nucleotide exchange factor 12
 
Protein also known as:  Leukemia-associated RhoGEF.
Gene name:  ARHGEF12
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.  
1
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor bindingdefinition[GO:0001664]  
1
  • IDAMGI
GTPase activator activitydefinition[GO:0005096]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IPIUniProtKB
  • IPIIntAct
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
  • IEAInterPro 2 GO
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDAMGI
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+23365  
Regulation of actin cytoskeleton  hsa04810+23365  
Tuberculosis  hsa05152+23365  
Vascular smooth muscle contraction  hsa04270+23365  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARHGEF12
GenomeRNAi: 23365
PRO: PR:Q9NZN5