C1RL - Complement C1r subcomponent-like protein - human protein (Function)
 
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C1RL »  Complement C1r subcomponent-like protein   [ EC 3.4.21.- ]  (C1r-LP)
 
Protein also known as:  C1r-like serine protease analog protein (CLSPa).
Gene name:  C1RL
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.  
3
  • CuratedUniProtKB
GO molecular function 
Serine-type endopeptidase activitydefinition[GO:0004252] silver  
  • IEAInterPro 2 GO
GO biological process 
Complement activation, classical pathwaydefinition[GO:0006958]  
  • IEAUniProtKB KW
Innate immune responsedefinition[GO:0045087]  
  • IEAUniProtKB KW
Enzymatic activity 
 
More information is available from:
Caution 
Does not associate with the C1 complex. According to PubMed15385675, doesn't cleave the proform of complement C1s.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Complement pathway  definition   [KW-0180]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 51279
PRO: PR:Q9NZP8