CD274 - Programmed cell death 1 ligand 1 - human protein (Function)
 
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CD274 »  Programmed cell death 1 ligand 1  (PD-L1)
 
Protein also known as:  B7 homolog 1 (B7-H1); CD antigen CD274.
Gene name:  CD274
Family name: Immunoglobulin » BTN/MOG
Entry whose protein(s) existence is based on evidence at protein level
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1 241 3
GENE REF ISO

Function

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Overview 
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.  
3
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • UniProtKB
Immune responsedefinition[GO:0006955]  
1
  • UniProtKB
Negative regulation of activated T cell proliferationdefinition[GO:0046007]  
1
  • UniProtKB
Negative regulation of interferon-gamma productiondefinition[GO:0032689]  
2
  • UniProtKB
Negative regulation of interleukin-10 productiondefinition[GO:0032693]  
2
  • UniProtKB
Negative regulation of tumor necrosis factor superfamily cytokine productiondefinition[GO:1903556]  
1
  • UniProtKB
Positive regulation of interleukin-10 secretiondefinition[GO:2001181]  
1
  • UniProtKB
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • UniProtKB
Not  Regulation of activated T cell proliferationdefinition[GO:0046006]  
2
  • UniProtKB
Not  Regulation of T cell apoptotic processdefinition[GO:0070232]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • UniProtKB
T cell costimulationdefinition[GO:0031295]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cell adhesion molecules (CAMs)  hsa04514+29126  
According to Reactome, this protein belongs to the following pathway:
PD-1 signaling  REACT_19324  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PD-L1
GenomeRNAi: 29126
PRO: PR:Q9NZQ7