CD274 - Programmed cell death 1 ligand 1 - human protein (Function)
 
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CD274 »  Programmed cell death 1 ligand 1  (PD-L1)
 
Protein also known as:  B7 homolog 1 (B7-H1); CD antigen CD274.
Gene name:  CD274
Family name: Immunoglobulin » BTN/MOG
Entry whose protein(s) existence is based on evidence at protein level
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1 218 3
GENE REF ISO

Function

 show evidences
Overview 
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • IDAUniProtKB
Immune responsedefinition[GO:0006955]  
1
  • IDAUniProtKB
Negative regulation of T cell proliferationdefinition[GO:0042130] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-10 secretiondefinition[GO:2001181]  
1
  • IDAUniProtKB
Positive regulation of T cell proliferationdefinition[GO:0042102]  
1
  • TASUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • IDAUniProtKB
T cell costimulationdefinition[GO:0031295]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cell adhesion molecules (CAMs)  hsa04514+29126  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PD-L1
GenomeRNAi: 29126
PRO: PR:Q9NZQ7