TRPM5 - Transient receptor potential cation channel subfamily M member 5 - human protein (Function)
 
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TRPM5 »  Transient receptor potential cation channel subfamily M member 5
 
Protein also known as:  Long transient receptor potential channel 5 (LTrpC5).
Gene name:  TRPM5
Entry whose protein(s) existence is based on evidence at transcript level
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1 25 3
GENE REF ISO

Function

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Overview 
Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the transient receptor potential ca(2+) channel (trp-cc) family  1.A.4.5.3  
GO molecular function 
Calcium activated cation channel activitydefinition[GO:0005227] silver  
  • IEAOrtholog Compara
Ion channel activitydefinition[GO:0005216]  
1
  • TASPINC
Potassium channel activitydefinition[GO:0005267] silver  
  • IEAOrtholog Compara
Sodium channel activitydefinition[GO:0005272] silver  
  • IEAOrtholog Compara
Voltage-gated ion channel activitydefinition[GO:0005244]  
  • IEAUniProtKB KW
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805] silver  
  • IEAOrtholog Compara
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Sodium ion transmembrane transportdefinition[GO:0035725] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Taste transduction  hsa04742+29850  
According to Reactome, this protein belongs to the following pathway:
TRP channels  REACT_169333  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPM5
GenomeRNAi: 29850
PRO: PR:Q9NZQ8
Chemistry
GuidetoPHARMACOLOGY: 497