PDP1 - [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial - human protein (Function)
 
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PDP1 »  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial   [ EC 3.1.3.43 ]  (PDP 1)
 
Protein also known as:  Pyruvate dehydrogenase phosphatase catalytic subunit 1 (PDPC 1).
Gene name:  PDP1
Family name: PP2C
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 31 2
GENE REF ISO

Function

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Overview 
Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity).  
  • CuratedUniProtKB
GO molecular function 
[pyruvate dehydrogenase (lipoamide)] phosphatase activitydefinition[GO:0004741]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein serine/threonine phosphatase activitydefinition[GO:0004722]  
1
  • IDAUniProtKB
GO biological process 
Peptidyl-threonine dephosphorylationdefinition[GO:0035970]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.43: [Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H(2)O [pyruvate dehydrogenase (acetyl-transferring)] + phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium ions per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Regulation of pyruvate dehydrogenase (PDH) complex  REACT_12528  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links