ADAM22 - Disintegrin and metalloproteinase domain-containing protein 22 - human protein (Function)
 
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ADAM22 »  Disintegrin and metalloproteinase domain-containing protein 22
 
Gene name:  ADAM22
Entry whose protein(s) existence is based on evidence at protein level
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1 42 5
GENE REF ISO

Function

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Overview 
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.  
3
  • CuratedUniProtKB
GO molecular function 
Integrin bindingdefinition[GO:0005178]  
1
  • NASUniProtKB
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
3
  • IPIDFLAT
  • IPIIntAct
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Adult locomotory behaviordefinition[GO:0008344] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Central nervous system developmentdefinition[GO:0007417]  
1
  • TASPINC
Myelination in peripheral nervous systemdefinition[GO:0022011] silver  
  • IEAOrtholog Compara
Negative regulation of cell adhesiondefinition[GO:0007162]  
1
  • NASUniProtKB
Proteolysisdefinition[GO:0006508] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
 
More information is available from:
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAM22
GenomeRNAi: 53616
PRO: PR:Q9P0K1