PKD2L1 - Polycystic kidney disease 2-like 1 protein - human protein (Function)
 
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PKD2L1 »  Polycystic kidney disease 2-like 1 protein
 
Protein also known as:  Polycystin-2 homolog.
Gene name:  PKD2L1
Family name: Polycystin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.  
4
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the polycystin cation channel (pcc) family  1.A.5.1.3  
GO molecular function 
Alpha-actinin bindingdefinition[GO:0051393]  
1
  • IPIBHF-UCL
Calcium activated cation channel activitydefinition[GO:0005227]  
2
  • IDABHF-UCL
Calcium channel activitydefinition[GO:0005262]  
1
  • IDAUniProtKB
  • IBARefGenome
Calcium ion bindingdefinition[GO:0005509]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Calcium-activated potassium channel activitydefinition[GO:0015269]  
1
  • IDABHF-UCL
Cation channel activitydefinition[GO:0005261]  
1
  • IDABHF-UCL
Contributes to cation transmembrane transporter activitydefinition[GO:0008324]  
  • ISSOrtholog Curator
Cytoskeletal protein bindingdefinition[GO:0008092]  
1
  • IPIUniProtKB
Identical protein bindingdefinition[GO:0042802]  
  • ISSOrtholog Curator
Muscle alpha-actinin bindingdefinition[GO:0051371]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
Sodium channel activitydefinition[GO:0005272]  
1
  • IDABHF-UCL
Contributes to sour taste receptor activitydefinition[GO:0033040]  
  • ISSOrtholog Curator
GO biological process 
Cation transportdefinition[GO:0006812]  
  • ISSOrtholog Curator
Cellular response to aciditydefinition[GO:0071468]  
  • ISSOrtholog Curator
Detection of chemical stimulus involved in sensory perception of sour tastedefinition[GO:0001581]  
  • ISSOrtholog Curator
Detection of mechanical stimulusdefinition[GO:0050982] silver  
  • IBARefGenome
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • IDABHF-UCL
Protein homotrimerizationdefinition[GO:0070207]  
1
  • IDAUniProtKB
Sensory perception of sour tastedefinition[GO:0050915]  
1
  • IMPUniProtKB
Smoothened signaling pathwaydefinition[GO:0007224]  
  • ISSOrtholog Curator
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • IDABHF-UCL
Enzymatic activity 
It is regulated in the following manner
The calcium channel is gated following an off-response property by acid: gated open after the removal of acid stimulus, but not during acid application.  
3
  • CuratedUniProtKB
Caution 
PKD1L3 and PKD2L1 have been defined as sour taste receptor in gustatory cells based on a number of indirect evidences in mouse. Some data confirm this hypothesis in human: in 2 patients with sour ageusia that are unresponsive to sour stimuli, but show normal responses to bitter, sweet, and salty stimuli, expression of PKD1L3 and PKD2L1 is absent in the anterior part of the tongue (PubMed19812697). However, a number of experiments have recently shown that the sour taste receptor activity is probably indirect.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PKD2L1
GenomeRNAi: 9033
PRO: PR:Q9P0L9
Chemistry
GuidetoPHARMACOLOGY: 505