TOMM7 - Mitochondrial import receptor subunit TOM7 homolog - human protein (Function)
 
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TOMM7 »  Mitochondrial import receptor subunit TOM7 homolog
 
Protein also known as:  Translocase of outer membrane 7 kDa subunit homolog.
Gene name:  TOMM7
Family name: Tom7
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Required for assembly and stability of the TOM complex. Positive regulator of PARK2 translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.  
3
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Contributes to protein channel activitydefinition[GO:0015266]  
1
  • RefGenome
Protein transmembrane transporter activitydefinition[GO:0008320]  
1
  • BHF-UCL
GO biological process 
Mitophagy in response to mitochondrial depolarizationdefinition[GO:0098779]  
1
  • ParkinsonsUK-UCL
Positive regulation of protein targeting to mitochondriondefinition[GO:1903955]  
1
  • ParkinsonsUK-UCL
Protein import into mitochondrial matrixdefinition[GO:0030150]  
1
  • RefGenome
Protein import into mitochondrial outer membranedefinition[GO:0045040]  
1
  • RefGenome
Protein targeting to mitochondriondefinition[GO:0006626]  
1
  • BHF-UCL
Regulation of protein stabilitydefinition[GO:0031647]  
1
  • ParkinsonsUK-UCL
Pathways 
According to Reactome, this protein belongs to the following pathways:
Mitochondrial protein import  R-HSA-1268020  
Pink/Parkin Mediated Mitophagy  R-HSA-5205685  
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 54543
PRO: PR:Q9P0U1