SENP1 - Sentrin-specific protease 1 - human protein (Function)
 
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References

 
SENP1 »  Sentrin-specific protease 1   [ EC 3.4.22.68 ]
 
Protein also known as:  Sentrin/SUMO-specific protease SENP1.
Gene name:  SENP1
Family name: Peptidase C48
Entry whose protein(s) existence is based on evidence at protein level
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1 31 2
GENE REF ISO

Function

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Overview 
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.  
4
  • CuratedUniProtKB
GO molecular function 
Endopeptidase activitydefinition[GO:0004175]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
SUMO-specific protease activitydefinition[GO:0016929]  
  • ISSOrtholog Curator
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • IMPUniProtKB
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • IMPUniProtKB
Negative regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032435] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IGIMGI
Protein desumoylationdefinition[GO:0016926]  
  • ISSOrtholog Curator
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Regulation of definitive erythrocyte differentiationdefinition[GO:0010724] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.68: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SENP1
GenomeRNAi: 29843
PRO: PR:Q9P0U3