SENP1 - Sentrin-specific protease 1 - human protein (Function)
 
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Protein
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References

 
SENP1 »  Sentrin-specific protease 1   [ EC 3.4.22.68 ]
 
Protein also known as:  Sentrin/SUMO-specific protease SENP1.
Gene name:  SENP1
Family name: Peptidase C48
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity.  
6
  • CuratedUniProtKB
GO molecular function 
Endopeptidase activitydefinition[GO:0004175]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
SUMO-specific protease activitydefinition[GO:0016929]  
  • ISSOrtholog Curator
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • IMPUniProtKB
Apoptotic signaling pathwaydefinition[GO:0097190]  
1
  • IMPUniProtKB
Negative regulation of proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0032435] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IGIMGI
Protein desumoylationdefinition[GO:0016926]  
  • ISSOrtholog Curator
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Regulation of definitive erythrocyte differentiationdefinition[GO:0010724] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.68: Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
SUMO is proteolytically processed  REACT_163725  
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SENP1
GenomeRNAi: 29843
PRO: PR:Q9P0U3