PIM2 - Serine/threonine-protein kinase pim-2 - human protein (Function)
 
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PIM2 »  Serine/threonine-protein kinase pim-2   [ EC 2.7.11.1 ]
 
Protein also known as:  Pim-2h.
Gene name:  PIM2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 42 1
GENE REF ISO

Function

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Overview 
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
GO biological process 
Apoptotic mitochondrial changesdefinition[GO:0008637] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
G1/S transition of mitotic cell cycledefinition[GO:0000082]  
1
  • IDAUniProtKB
Male meiosisdefinition[GO:0007140]  
1
  • TASPINC
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDAUniProtKB
Positive regulation of autophagydefinition[GO:0010508]  
  • ISSOrtholog Curator
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Protein stabilizationdefinition[GO:0050821]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Response to virusdefinition[GO:0009615]  
1
  • IEPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Acute myeloid leukemia  hsa05221+11040  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cell cycle  definition   [KW-0131]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PIM2_(gene)
GenomeRNAi: 11040
PRO: PR:Q9P1W9
Chemistry
GuidetoPHARMACOLOGY: 2159