CALCOCO1 - Calcium-binding and coiled-coil domain-containing protein 1 - human protein (Function)
 
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CALCOCO1 »  Calcium-binding and coiled-coil domain-containing protein 1
 
Protein also known as:  Coiled-coil coactivator protein.
Gene name:  CALCOCO1
Family name: CALCOCO
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity).  
  • CuratedUniProtKB
Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.  
  • CuratedUniProtKB
GO molecular function 
Armadillo repeat domain bindingdefinition[GO:0070016]  
1
  • IPIUniProtKB
Beta-catenin bindingdefinition[GO:0008013]  
1
  • IPIAgBase
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Ligand-dependent nuclear receptor transcription coactivator activitydefinition[GO:0030374]  
1
  • IDAAgBase
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • IPIUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAAgBase
Transcription coactivator activitydefinition[GO:0003713]  
1
  • IMPUniProtKB
  • ISSOrtholog Curator
Transcription cofactor activitydefinition[GO:0003712]  
1
  • IDAUniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
GO biological process 
Intracellular steroid hormone receptor signaling pathwaydefinition[GO:0030518]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IMPUniProtKB
Signal transductiondefinition[GO:0007165]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • ISSOrtholog Curator
Wnt signaling pathwaydefinition[GO:0016055]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CALCOCO1
GenomeRNAi: 57658
PRO: PR:Q9P1Z2