HCN3 - Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 - human protein (Function)
 
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Protein
Gene
References

 
HCN3 »  Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
 
Gene name:  HCN3
Family name: Potassium channel HCN
Entry whose protein(s) existence is based on evidence at transcript level
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GENE REF ISO

Function

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Overview 
Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.  
1
  • CuratedUniProtKB
GO molecular function 
cAMP bindingdefinition[GO:0030552]  
  • IEAUniProtKB KW
Voltage-gated potassium channel activitydefinition[GO:0005249]  
1
  • IMPUniProtKB
  • IBARefGenome
Voltage-gated sodium channel activitydefinition[GO:0005248]  
1
  • IMPUniProtKB
GO biological process 
Not  Cellular response to cAMPdefinition[GO:0071320]  
1
  • IDAUniProtKB
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • IMPUniProtKB
  • IBARefGenome
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IMPUniProtKB
  • IBARefGenome
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • IMPUniProtKB
Enzymatic activity 
It is regulated in the following manner
Inhibited by Cs(1+) and ZD7288. Is apparently not activated by cAMP.  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Potassium channel  definition   [KW-0631]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: HCN3
GenomeRNAi: 57657
PRO: PR:Q9P1Z3
Chemistry
GuidetoPHARMACOLOGY: 402