PAK7 - Serine/threonine-protein kinase PAK 7 - human protein (Function)
 
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PAK7 »  Serine/threonine-protein kinase PAK 7   [ EC 2.7.11.1 ]
 
Protein also known as:  p21-activated kinase 7 (PAK-7).
Gene name:  PAK7
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IBARefGenome
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASUniProtKB
Cell growthdefinition[GO:0016049]  
1
  • TASUniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • TASUniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • TASUniProtKB
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • TASUniProtKB
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IBARefGenome
Not  Mitotic cell cycledefinition[GO:0000278] silver  
  • IBARefGenome
Negative regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001237] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASUniProtKB
Signal transduction by phosphorylationdefinition[GO:0023014] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+57144  
ErbB signaling pathway  hsa04012+57144  
Focal adhesion  hsa04510+57144  
Regulation of actin cytoskeleton  hsa04810+57144  
Renal cell carcinoma  hsa05211+57144  
T cell receptor signaling pathway  hsa04660+57144  
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PAK7
GenomeRNAi: 57144
PRO: PR:Q9P286
Chemistry
GuidetoPHARMACOLOGY: 2138