MST4 - Serine/threonine-protein kinase MST4 - human protein (Function)
 
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MST4 »  Serine/threonine-protein kinase MST4   [ EC 2.7.11.1 ]
 
Protein also known as:  Mammalian STE20-like protein kinase 4 (MST-4).
Gene name:  MST4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Mediator of cell growth. Modulates apoptosis.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
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  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
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  • IPIIntAct
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Protein kinase activitydefinition[GO:0004672]  
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  • IDAUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
GO biological process 
Protein phosphorylationdefinition[GO:0006468]  
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  • IDAUniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
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  • IDAUniProtKB
Signal transduction by phosphorylationdefinition[GO:0023014] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage.  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Apoptotic cleavage of cellular proteins  REACT_107  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MST4
GenomeRNAi: 51765
PRO: PR:Q9P289
Chemistry
GuidetoPHARMACOLOGY: 2287