C5AR2 - C5a anaphylatoxin chemotactic receptor 2 - human protein (Function)
 
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C5AR2 »  C5a anaphylatoxin chemotactic receptor 2
 
Protein also known as:  Complement component 5a receptor 2.
Gene name:  C5AR2
Entry whose protein(s) existence is based on evidence at protein level
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1 43 1
GENE REF ISO

Function

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Overview 
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.  
3
  • CuratedUniProtKB
GO molecular function 
C5a anaphylatoxin receptor activitydefinition[GO:0004944] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Chemotaxisdefinition[GO:0006935] silver  
  • IEAInterPro 2 GO
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAInterPro 2 GO
Negative regulation of interleukin-6 secretiondefinition[GO:1900165]  
1
  • IMPUniProtKB
Negative regulation of neutrophil chemotaxisdefinition[GO:0090024]  
1
  • IMPUniProtKB
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720]  
1
  • IMPUniProtKB
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IEAInterPro 2 GO
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374] silver  
  • IEAInterPro 2 GO
Regulation of interleukin-8 secretiondefinition[GO:2000482]  
1
  • IMPUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GPR77
GenomeRNAi: 27202
PRO: PR:Q9P296
Chemistry
GuidetoPHARMACOLOGY: 33