ADAMTS9 - A disintegrin and metalloproteinase with thrombospondin motifs 9 - human protein (Function)
 
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ADAMTS9 »  A disintegrin and metalloproteinase with thrombospondin motifs 9   [ EC 3.4.24.- ]  (ADAMTS-9)
 
Gene name:  ADAMTS9
Entry whose protein(s) existence is based on evidence at protein level
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1 49 4
GENE REF ISO

Function

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Overview 
Cleaves the large aggregating proteoglycans, aggrecan and versican. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos.  
2
  • CuratedUniProtKB
GO molecular function 
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Metallopeptidase activitydefinition[GO:0008237]  
1
  • IDAMGI
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Glycoprotein catabolic processdefinition[GO:0006516]  
1
  • TASPINC
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Positive regulation of melanocyte differentiationdefinition[GO:0045636] silver  
  • IEAOrtholog Compara
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
Proteolysisdefinition[GO:0006508]  
1
  • IDAMGI
Vesicle-mediated transportdefinition[GO:0016192]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.-: Cleaves aggrecan at the 1838-Glu-|-Ala-1839 site and versican at the 1428-Glu-|-Ala-1429 site.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Extracellular matrix organization  REACT_223425  
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
ER-Golgi transport  definition   [KW-0931]
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAMTS9
GenomeRNAi: 56999
PRO: PR:Q9P2N4