SLC17A7 - Vesicular glutamate transporter 1 - human protein (Function)
 
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Protein
Gene
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SLC17A7 »  Vesicular glutamate transporter 1  (VGluT1)
 
Protein also known as:  Brain-specific Na(+)-dependent inorganic phosphate cotransporter.
Gene name:  SLC17A7
Entry whose protein(s) existence is based on evidence at protein level
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1 31 3
GENE REF ISO

Function

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Overview 
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.14.30  
GO molecular function 
Extracellular-glutamate-gated chloride channel activitydefinition[GO:0008068] silver  
1
  • Ortholog Compara
Inorganic phosphate transmembrane transporter activitydefinition[GO:0005315] silver  
1
  • Ortholog Compara
Sodium-dependent phosphate transmembrane transporter activitydefinition[GO:0015321] silver  
1
  • Ortholog Compara
Sodium:inorganic phosphate symporter activitydefinition[GO:0015319]  
1
  • MGI
GO biological process 
Chloride transmembrane transportdefinition[GO:1902476] silver  
1
  • Ortholog Compara
Excitatory postsynaptic potentialdefinition[GO:0060079] silver  
1
  • Ortholog Compara
L-glutamate importdefinition[GO:0051938] silver  
1
  • Ortholog Compara
Long-term memorydefinition[GO:0007616] silver  
1
  • Ortholog Compara
Phosphate ion transmembrane transportdefinition[GO:0035435]  
1
  • GOC
Phosphate ion transportdefinition[GO:0006817]  
1
  • PINC
Sequestering of neurotransmitterdefinition[GO:0042137] silver  
1
  • Ortholog Compara
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • GOC
Sodium-dependent phosphate transportdefinition[GO:0044341]  
1
  • RefGenome
Synaptic transmission, glutamatergicdefinition[GO:0035249] silver  
1
  • Ortholog Compara
Synaptic vesicle lumen acidificationdefinition[GO:0097401] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glutamatergic synapse  hsa04724+57030  
Synaptic vesicle cycle  hsa04721+57030  
According to Reactome, this protein belongs to the following pathways:
Glutamate Neurotransmitter Release Cycle  R-HSA-210500  
Organic anion transporters  R-HSA-428643  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Neurotransmitter transport  definition   [KW-0532]
Sodium transport  definition   [KW-0739]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links