HLA-C - HLA class I histocompatibility antigen, Cw-5 alpha chain - human protein (Function)
 
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Protein
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HLA-C »  HLA class I histocompatibility antigen, Cw-5 alpha chain
 
Protein also known as:  MHC class I antigen Cw*5.
Gene name:  HLA-C
Family name: MHC class I
Entry whose protein(s) existence is based on evidence at protein level
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2 566 1
GENE REF ISO

Function

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Overview 
Involved in the presentation of foreign antigens to the immune system.  
  • CuratedUniProtKB
GO molecular function 
Peptide antigen bindingdefinition[GO:0042605]  
  • ISSOrtholog Curator
GO biological process 
Positive regulation of T cell mediated cytotoxicitydefinition[GO:0001916] silver  
  • IEAInterPro 2 GO
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Allograft rejection  hsa05330+3107  
Antigen processing and presentation  hsa04612+3107  
Autoimmune thyroid disease  hsa05320+3107  
Cell adhesion molecules (CAMs)  hsa04514+3107  
Endocytosis  hsa04144+3107  
Graft-versus-host disease  hsa05332+3107  
Herpes simplex infection  hsa05168+3107  
HTLV-I infection  hsa05166+3107  
Natural killer cell mediated cytotoxicity  hsa04650+3107  
Phagosome  hsa04145+3107  
Type I diabetes mellitus  hsa04940+3107  
Viral myocarditis  hsa05416+3107  
According to Reactome, this protein belongs to the following pathways:
Antigen Presentation: Folding, assembly and peptide loading of class I MHC  REACT_75795  
Endosomal/Vacuolar pathway  REACT_111168  
ER-Phagosome pathway  REACT_111178  
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell  REACT_11152  
Interferon alpha/beta signaling  REACT_25162  
Interferon gamma signaling  REACT_25078  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Immunity  definition   [KW-0391]
Technical term 
Reference proteome  definition   [KW-1185]