CLCF1 - Cardiotrophin-like cytokine factor 1 - human protein (Function)
 
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Protein
Gene
References

 
CLCF1 »  Cardiotrophin-like cytokine factor 1
 
Protein also known as:  B-cell-stimulating factor 3 (BSF-3).
Gene name:  CLCF1
Family name: IL-6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 19 2
GENE REF ISO

Function

 show evidences
Overview 
Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor.  
2
  • CuratedUniProtKB
GO molecular function 
Contributes to ciliary neurotrophic factor receptor bindingdefinition[GO:0005127]  
2
  • IDABHF-UCL
Contributes to cytokine activitydefinition[GO:0005125]  
2
  • IDABHF-UCL
  • NASUniProtKB
Growth factor activitydefinition[GO:0008083]  
1
  • TASHGNC
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IDABHF-UCL
Receptor bindingdefinition[GO:0005102]  
1
  • IPIHGNC
GO biological process 
B cell differentiationdefinition[GO:0030183]  
  • ISSOrtholog Curator
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
  • ISSOrtholog Curator
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • NASUniProtKB
JAK-STAT cascadedefinition[GO:0007259]  
  • ISSOrtholog Curator
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
2
  • IDABHF-UCL
Positive regulation of astrocyte differentiationdefinition[GO:0048711]  
  • ISSOrtholog Curator
Positive regulation of B cell proliferationdefinition[GO:0030890]  
  • ISSOrtholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IDABHF-UCL
Positive regulation of immunoglobulin productiondefinition[GO:0002639]  
  • ISSOrtholog Curator
Positive regulation of isotype switching to IgE isotypesdefinition[GO:0048295]  
  • ISSOrtholog Curator
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517]  
3
  • TASHGNC
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+23529  
Jak-STAT signaling pathway  hsa04630+23529  
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CLCF1
GenomeRNAi: 23529
PRO: PR:Q9UBD9