GNG12 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 - human protein (Function)
 
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GNG12 »  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
 
Gene name:  GNG12
Family name: G protein gamma
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.  
  • CuratedUniProtKB
GO molecular function 
PDZ domain bindingdefinition[GO:0030165]  
1
  • IDAMGI
Phosphate ion bindingdefinition[GO:0042301] silver  
  • IEAOrtholog Compara
Signal transducer activitydefinition[GO:0004871]  
  • IEAUniProtKB KW
GO biological process 
Cerebral cortex developmentdefinition[GO:0021987] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186] silver  
  • IEAInterPro 2 GO
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+55970  
Cholinergic synapse  hsa04725+55970  
Dopaminergic synapse  hsa04728+55970  
GABAergic synapse  hsa04727+55970  
Glutamatergic synapse  hsa04724+55970  
MAPK signaling pathway  hsa04010+55970  
Regulation of actin cytoskeleton  hsa04810+55970  
According to Reactome, this protein belongs to the following pathways:
Activation of G protein gated Potassium channels  REACT_75831  
ADP signalling through P2Y purinoceptor 1  REACT_19140  
ADP signalling through P2Y purinoceptor 12  REACT_20653  
Adrenaline,noradrenaline inhibits insulin secretion  REACT_18339  
Ca2+ pathway  REACT_172761  
G alpha (12/13) signalling events  REACT_18407  
G alpha (i) signalling events  REACT_19231  
G alpha (q) signalling events  REACT_18283  
G alpha (s) signalling events  REACT_19327  
G alpha (z) signalling events  REACT_19333  
G beta:gamma signalling through PI3Kgamma  REACT_19290  
G beta:gamma signalling through PLC beta  REACT_19145  
G-protein activation  REACT_15457  
Glucagon signaling in metabolic regulation  REACT_1665  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  REACT_18274  
Glucagon-type ligand receptors  REACT_18377  
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits  REACT_25004  
Presynaptic function of Kainate receptors  REACT_21254  
Prostacyclin signalling through prostacyclin receptor  REACT_23946  
Regulation of water balance by renal Aquaporins  REACT_24023  
Thrombin signalling through proteinase activated receptors (PARs)  REACT_21384  
Thromboxane signalling through TP receptor  REACT_20647  
 

Keywords

Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GNG12
GenomeRNAi: 55970
PRO: PR:Q9UBI6