PPARGC1A - Peroxisome proliferator-activated receptor gamma coactivator 1-alpha - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
PPARGC1A »  Peroxisome proliferator-activated receptor gamma coactivator 1-alpha  (PGC-1-alpha)
 
Protein also known as:  Ligand effect modulator 6.
Gene name:  PPARGC1A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 310 9
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.  
5
  • UniProtKB
GO molecular function 
Androgen receptor bindingdefinition[GO:0050681]  
1
  • UniProtKB
Chromatin DNA bindingdefinition[GO:0031490]  
1
  • Ortholog Curator
DNA bindingdefinition[GO:0003677]  
2
  • UniProtKB
  • Ortholog Curator
Ligand-dependent nuclear receptor bindingdefinition[GO:0016922]  
1
  • UniProtKB
Ligand-dependent nuclear receptor transcription coactivator activitydefinition[GO:0030374]  
1
  • BHF-UCL
Nucleotide bindingdefinition[GO:0000166] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
RNA bindingdefinition[GO:0003723]  
1
  • UniProtKB
RNA polymerase II transcription cofactor activitydefinition[GO:0001104]  
1
  • UniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • UniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
2
  • UniProtKB
  • BHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
GO biological process 
Androgen metabolic processdefinition[GO:0008209] silver  
1
  • Ortholog Compara
Androgen receptor signaling pathwaydefinition[GO:0030521]  
1
  • UniProtKB
Brown fat cell differentiationdefinition[GO:0050873]  
1
  • UniProtKB
Cellular glucose homeostasisdefinition[GO:0001678]  
1
  • UniProtKB
Cellular respirationdefinition[GO:0045333]  
1
  • UniProtKB
Cellular response to fatty aciddefinition[GO:0071398] silver  
1
  • Ortholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
1
  • Ortholog Compara
Cellular response to nitritedefinition[GO:0071250] silver  
1
  • Ortholog Compara
Cellular response to oxidative stressdefinition[GO:0034599]  
1
  • Ortholog Curator
Cellular response to thyroid hormone stimulusdefinition[GO:0097067] silver  
1
  • Ortholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
1
  • Ortholog Compara
Circadian regulation of gene expressiondefinition[GO:0032922]  
1
  • Ortholog Curator
Digestiondefinition[GO:0007586]  
1
  • UniProtKB
Fatty acid oxidationdefinition[GO:0019395]  
1
  • UniProtKB
Flavone metabolic processdefinition[GO:0051552] silver  
1
  • Ortholog Compara
Galactose metabolic processdefinition[GO:0006012] silver  
1
  • Ortholog Compara
Gluconeogenesisdefinition[GO:0006094]  
1
  • UniProtKB
Mitochondrion organizationdefinition[GO:0007005]  
1
  • UniProtKB
mRNA processingdefinition[GO:0006397]  
1
  • UniProtKB
Negative regulation of glycolytic processdefinition[GO:0045820] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • Ortholog Curator
Negative regulation of neuron deathdefinition[GO:1901215]  
1
  • UniProtKB
Negative regulation of receptor activitydefinition[GO:2000272] silver  
1
  • Ortholog Compara
Positive regulation of ATP biosynthetic processdefinition[GO:2001171]  
1
  • Ortholog Curator
Positive regulation of cellular respirationdefinition[GO:1901857] silver  
1
  • Ortholog Compara
Positive regulation of energy homeostasisdefinition[GO:2000507]  
1
  • Ortholog Curator
Positive regulation of fatty acid oxidationdefinition[GO:0046321]  
1
  • UniProtKB
Positive regulation of gluconeogenesisdefinition[GO:0045722]  
1
  • UniProtKB
Positive regulation of histone acetylationdefinition[GO:0035066]  
1
  • UniProtKB
Positive regulation of mitochondrial DNA metabolic processdefinition[GO:1901860] silver  
1
  • Ortholog Compara
Positive regulation of mitochondrion organizationdefinition[GO:0010822]  
2
  • Ortholog Curator
  • RefGenome
Positive regulation of muscle tissue developmentdefinition[GO:1901863] silver  
1
  • Ortholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • BHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • ParkinsonsUK-UCL
  • Ortholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
3
  • BHF-UCL
  • UniProtKB
Protein complex assemblydefinition[GO:0006461]  
1
  • UniProtKB
Protein stabilizationdefinition[GO:0050821]  
1
  • UniProtKB
Regulation of circadian rhythmdefinition[GO:0042752]  
1
  • Ortholog Curator
Regulation of N-methyl-D-aspartate selective glutamate receptor activitydefinition[GO:2000310] silver  
1
  • Ortholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Respiratory electron transport chaindefinition[GO:0022904]  
1
  • Ortholog Curator
Response to colddefinition[GO:0009409] silver  
1
  • Ortholog Compara
Response to epinephrinedefinition[GO:0071871] silver  
1
  • Ortholog Compara
Response to leucinedefinition[GO:0043201] silver  
1
  • Ortholog Compara
Response to muscle activitydefinition[GO:0014850]  
1
  • Ortholog Curator
Response to norepinephrinedefinition[GO:0071873] silver  
1
  • Ortholog Compara
Response to starvationdefinition[GO:0042594]  
1
  • UniProtKB
Response to statindefinition[GO:0036273] silver  
1
  • Ortholog Compara
RNA splicingdefinition[GO:0008380]  
1
  • UniProtKB
Temperature homeostasisdefinition[GO:0001659]  
1
  • UniProtKB
Transcription initiation from RNA polymerase II promoterdefinition[GO:0006367]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+10891  
Huntington's disease  hsa05016+10891  
Insulin signaling pathway  hsa04910+10891  
According to Reactome, this protein belongs to the following pathways:
Activation of PPARGC1A (PGC-1alpha) by phosphorylation  REACT_264544  
BMAL1:CLOCK,NPAS2 activates circadian gene expression  REACT_111118  
Circadian Clock  REACT_24941  
PPARA activates gene expression  REACT_116145  
REV-ERBA represses gene expression  REACT_118789  
RORA activates circadian gene expression  REACT_118659  
Transcriptional activation of mitochondrial biogenesis  REACT_264212  
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPARGC1A
GenomeRNAi: 10891
PRO: PR:Q9UBK2