PPARGC1A - Peroxisome proliferator-activated receptor gamma coactivator 1-alpha - human protein (Function)
 
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PPARGC1A »  Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
 
Gene name:  PPARGC1A
Entry whose protein(s) existence is based on evidence at protein level
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1 282 9
GENE REF ISO

Function

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Overview 
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.  
4
  • CuratedUniProtKB
GO molecular function 
Androgen receptor bindingdefinition[GO:0050681]  
1
  • NASUniProtKB
Chromatin DNA bindingdefinition[GO:0031490]  
  • ISSOrtholog Curator
DNA bindingdefinition[GO:0003677]  
1
  • TASUniProtKB
  • ISSOrtholog Curator
Ligand-dependent nuclear receptor bindingdefinition[GO:0016922]  
1
  • IPIUniProtKB
Ligand-dependent nuclear receptor transcription coactivator activitydefinition[GO:0030374]  
1
  • IDABHF-UCL
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
RNA bindingdefinition[GO:0003723]  
1
  • TASUniProtKB
RNA polymerase II transcription cofactor activitydefinition[GO:0001104]  
1
  • TASUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAUniProtKB
Transcription coactivator activitydefinition[GO:0003713]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
1
  • TASUniProtKB
GO biological process 
Androgen metabolic processdefinition[GO:0008209] silver  
  • IEAOrtholog Compara
Androgen receptor signaling pathwaydefinition[GO:0030521]  
1
  • NASUniProtKB
Brown fat cell differentiationdefinition[GO:0050873]  
1
  • TASUniProtKB
Cellular glucose homeostasisdefinition[GO:0001678]  
1
  • NASUniProtKB
Cellular respirationdefinition[GO:0045333]  
1
  • TASUniProtKB
Cellular response to fatty aciddefinition[GO:0071398] silver  
  • IEAOrtholog Compara
Cellular response to hypoxiadefinition[GO:0071456] silver  
  • IEAOrtholog Compara
Cellular response to nitritedefinition[GO:0071250] silver  
  • IEAOrtholog Compara
Cellular response to oxidative stressdefinition[GO:0034599]  
  • ISSOrtholog Curator
Cellular response to thyroid hormone stimulusdefinition[GO:0097067] silver  
  • IEAOrtholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
  • IEAOrtholog Compara
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
Digestiondefinition[GO:0007586]  
1
  • TASUniProtKB
Fatty acid oxidationdefinition[GO:0019395]  
1
  • NASUniProtKB
Flavone metabolic processdefinition[GO:0051552] silver  
  • IEAOrtholog Compara
Galactose metabolic processdefinition[GO:0006012] silver  
  • IEAOrtholog Compara
Gluconeogenesisdefinition[GO:0006094]  
1
  • NASUniProtKB
Mitochondrion organizationdefinition[GO:0007005]  
1
  • NASUniProtKB
mRNA processingdefinition[GO:0006397]  
1
  • TASUniProtKB
Negative regulation of glycolytic processdefinition[GO:0045820] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
  • ISSOrtholog Curator
Negative regulation of receptor activitydefinition[GO:2000272] silver  
  • IEAOrtholog Compara
Neuron deathdefinition[GO:0070997]  
1
  • IDAUniProtKB
Positive regulation of ATP biosynthetic processdefinition[GO:2001171]  
  • ISSOrtholog Curator
Positive regulation of cellular respirationdefinition[GO:1901857] silver  
  • IEAOrtholog Compara
Positive regulation of energy homeostasisdefinition[GO:2000507]  
  • ISSOrtholog Curator
Positive regulation of fatty acid oxidationdefinition[GO:0046321]  
1
  • TASUniProtKB
Positive regulation of gluconeogenesisdefinition[GO:0045722]  
1
  • TASUniProtKB
Positive regulation of histone acetylationdefinition[GO:0035066]  
1
  • TASUniProtKB
Positive regulation of mitochondrial DNA metabolic processdefinition[GO:1901860] silver  
  • IEAOrtholog Compara
Positive regulation of mitochondrion organizationdefinition[GO:0010822]  
  • ISSOrtholog Curator
Positive regulation of muscle tissue developmentdefinition[GO:1901863] silver  
  • IEAOrtholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IDABHF-UCL
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAParkinsonsUK-UCL
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
3
  • IDABHF-UCL
  • NASUniProtKB
Protein complex assemblydefinition[GO:0006461]  
1
  • TASUniProtKB
Protein stabilizationdefinition[GO:0050821]  
1
  • TASUniProtKB
Regulation of cell deathdefinition[GO:0010941]  
1
  • IDAUniProtKB
Regulation of circadian rhythmdefinition[GO:0042752]  
  • ISSOrtholog Curator
Regulation of N-methyl-D-aspartate selective glutamate receptor activitydefinition[GO:2000310] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAUniProtKB
Respiratory electron transport chaindefinition[GO:0022904]  
  • ISSOrtholog Curator
Response to colddefinition[GO:0009409] silver  
  • IEAOrtholog Compara
Response to epinephrinedefinition[GO:0071871] silver  
  • IEAOrtholog Compara
Response to leucinedefinition[GO:0043201] silver  
  • IEAOrtholog Compara
Response to muscle activitydefinition[GO:0014850]  
  • ISSOrtholog Curator
Response to norepinephrinedefinition[GO:0071873] silver  
  • IEAOrtholog Compara
Response to starvationdefinition[GO:0042594]  
1
  • NASUniProtKB
Response to statindefinition[GO:0036273] silver  
  • IEAOrtholog Compara
RNA splicingdefinition[GO:0008380]  
1
  • TASUniProtKB
Temperature homeostasisdefinition[GO:0001659]  
1
  • TASUniProtKB
Transcription initiation from RNA polymerase II promoterdefinition[GO:0006367]  
1
  • TASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+10891  
Huntington's disease  hsa05016+10891  
Insulin signaling pathway  hsa04910+10891  
According to Reactome, this protein belongs to the following pathways:
Activation of PPARGC1A (PGC-1alpha) by phosphorylation  REACT_200686  
BMAL1:CLOCK,NPAS2 activates circadian gene expression  REACT_111118  
Circadian Clock  REACT_24941  
PPARA activates gene expression  REACT_116145  
REV-ERBA represses gene expression  REACT_118789  
RORA activates circadian gene expression  REACT_118659  
Transcriptional activation of mitochondrial biogenesis  REACT_200608  
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPARGC1A
GenomeRNAi: 10891
PRO: PR:Q9UBK2