MTRR - Methionine synthase reductase - human protein (Function)
 
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MTRR »  Methionine synthase reductase   [ EC 1.16.1.8 ]  (MSR)
 
Gene name:  MTRR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects.  
1
  • CuratedUniProtKB
GO molecular function 
[methionine synthase] reductase activitydefinition[GO:0030586]  
2
  • TASUniProtKB
Flavin adenine dinucleotide bindingdefinition[GO:0050660]  
2
  • IDAUniProtKB
FMN bindingdefinition[GO:0010181]  
1
  • TASUniProtKB
Iron ion bindingdefinition[GO:0005506] silver  
  • IEAInterPro 2 GO
NADP bindingdefinition[GO:0050661]  
1
  • TASUniProtKB
Not  NADPH-hemoprotein reductase activitydefinition[GO:0003958] silver  
  • IBARefGenome
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygendefinition[GO:0016709] silver  
  • IBARefGenome
Oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptordefinition[GO:0016723]  
1
  • IDAUniProtKB
GO biological process 
DNA methylationdefinition[GO:0006306]  
  • ISSOrtholog Curator
Folic acid metabolic processdefinition[GO:0046655]  
  • ISSOrtholog Curator
Methionine biosynthetic processdefinition[GO:0009086]  
  • IEAUniProtKB KW
Methionine metabolic processdefinition[GO:0006555]  
1
  • TASUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.16.1.8: 2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP(+) 2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine.  
1
  • CuratedUniProtKB
It requires the following cofactors
FAD.  
1
  • CuratedUniProtKB
FMN.  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Cobalamin (Cbl, vitamin B12) transport and metabolism  REACT_163862  
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG  REACT_169149  
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE  REACT_169439  
Methylation  REACT_6946  
Sulfur amino acid metabolism  REACT_115639  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 3540 uM for NADH
KM 2.89 uM for NADPH

Keywords

Biological process 
Amino-acid biosynthesis  definition   [KW-0028]
Methionine biosynthesis  definition   [KW-0486]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9UBK8
Other
GeneWiki: MTRR_(gene)
GenomeRNAi: 4552
PRO: PR:Q9UBK8