ASH2L - Set1/Ash2 histone methyltransferase complex subunit ASH2 - human protein (Function)
 
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ASH2L »  Set1/Ash2 histone methyltransferase complex subunit ASH2
 
Gene name:  ASH2L
Entry whose protein(s) existence is based on evidence at protein level
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1 54 3
GENE REF ISO

Function

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Overview 
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.  
2
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • ICUniProtKB
Contributes to histone methyltransferase activity (H3-K4 specific)definition[GO:0042800]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
12
  • IPIIntAct
  • IPIUniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
GO biological process 
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • IDAMGI
Hemopoiesisdefinition[GO:0030097]  
1
  • NASUniProtKB
Histone H3-K4 methylationdefinition[GO:0051568]  
2
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IMPUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASUniProtKB
Response to estrogendefinition[GO:0043627]  
1
  • IDAUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • NASUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
deactivation of the beta-catenin transactivating complex  REACT_200731  
formation of the beta-catenin:TCF transactivating complex  REACT_200753  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ASH2L
GenomeRNAi: 9070
PRO: PR:Q9UBL3