DHCR7 - 7-dehydrocholesterol reductase - human protein (Function)
 
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DHCR7 »  7-dehydrocholesterol reductase   [ EC 1.3.1.21 ]  (7-DHC reductase)
 
Protein also known as:  Putative sterol reductase SR-2.
Gene name:  DHCR7
Family name: ERG4/ERG24
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).  
  • CuratedUniProtKB
GO molecular function 
7-dehydrocholesterol reductase activitydefinition[GO:0047598]  
1
  • IDAUniProtKB
GO biological process 
Blood vessel developmentdefinition[GO:0001568] silver  
  • IEAOrtholog Compara
Cell differentiationdefinition[GO:0030154] silver  
  • IEAOrtholog Compara
Cholesterol biosynthetic processdefinition[GO:0006695]  
1
  • IMPUniProtKB
  • IEAUniPathway
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Regulation of cholesterol biosynthetic processdefinition[GO:0045540] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.3.1.21: Cholesterol + NADP(+) cholesta-5,7-dien-3-beta-ol + NADPH.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+1717  
Steroid biosynthesis  hsa00100+1717  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Cholesterol biosynthesis  definition   [KW-0152]
Cholesterol metabolism  definition   [KW-0153]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Steroid biosynthesis  definition   [KW-0752]
Steroid metabolism  definition   [KW-0753]
Sterol biosynthesis  definition   [KW-0756]
Sterol metabolism  definition   [KW-1207]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9UBM7
Other
GeneWiki: 7-Dehydrocholesterol_reductase
GenomeRNAi: 1717
PRO: PR:Q9UBM7