CACNG4 - Voltage-dependent calcium channel gamma-4 subunit - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CACNG4 »  Voltage-dependent calcium channel gamma-4 subunit
 
Protein also known as:  Neuronal voltage-gated calcium channel gamma-4 subunit.
Gene name:  CACNG4
Family name: PMP-22/EMP/MP20 » CACNG
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 16 1
GENE REF ISO

Function

 show evidences
Overview 
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(+) channel auxiliary subunit 1-8 (cca) family  8.A.16.2.3  
GO molecular function 
Voltage-gated calcium channel activitydefinition[GO:0005245] silver  
  • IEAInterPro 2 GO
GO biological process 
Regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activitydefinition[GO:2000311]  
1
  • IDAUniProtKB
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+27092  
Cardiac muscle contraction  hsa04260+27092  
Dilated cardiomyopathy  hsa05414+27092  
Hypertrophic cardiomyopathy (HCM)  hsa05410+27092  
MAPK signaling pathway  hsa04010+27092  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CACNG4
GenomeRNAi: 27092
PRO: PR:Q9UBN1