TRPC4 - Short transient receptor potential channel 4 - human protein (Function)
 
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TRPC4 »  Short transient receptor potential channel 4  (TrpC4)
 
Protein also known as:  Trp-related protein 4.
Gene name:  TRPC4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.  
2
  • CuratedUniProtKB
GO molecular function 
Beta-catenin bindingdefinition[GO:0008013]  
1
  • IPIBHF-UCL
Cadherin bindingdefinition[GO:0045296]  
1
  • IPIBHF-UCL
Inositol 1,4,5 trisphosphate bindingdefinition[GO:0070679] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
Store-operated calcium channel activitydefinition[GO:0015279]  
1
  • IMPUniProtKB
GO biological process 
Calcium ion importdefinition[GO:0070509]  
1
  • IDABHF-UCL
Calcium ion transportdefinition[GO:0006816]  
1
  • TASPINC
Gamma-aminobutyric acid secretiondefinition[GO:0014051] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Transmembrane transport of small molecules  REACT_15518  
Note 
The interaction with spectrin is important in controlling the translocation of TRPC4 channels to the plasma membrane following EGF stimulation.  
  • CuratedUniProtKB
The cell membrane presentation, the calcium entry function and the interaction with junctional proteins (CTNNB1 and CDH5) are controlled by endothelial cell-cell contacts.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPC4
GenomeRNAi: 7223
PRO: PR:Q9UBN4
Chemistry
GuidetoPHARMACOLOGY: 489