HDAC6 - Histone deacetylase 6 - human protein (Function)
 
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HDAC6 »  Histone deacetylase 6   [ EC 3.5.1.98 ]  (HD6)
 
Gene name:  HDAC6
Family name: Histone deacetylase » HD type 2
Entry whose protein(s) existence is based on evidence at protein level
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1 157 2
GENE REF ISO

Function

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Overview 
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.  
2
  • CuratedUniProtKB
In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.  
2
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • IEAUniProtKB KW
Alpha-tubulin bindingdefinition[GO:0043014]  
1
  • IDABHF-UCL
Beta-catenin bindingdefinition[GO:0008013]  
1
  • IPIBHF-UCL
Beta-tubulin bindingdefinition[GO:0048487] silver  
  • IEAOrtholog Compara
Dynein complex bindingdefinition[GO:0070840]  
1
  • IDABHF-UCL
Enzyme bindingdefinition[GO:0019899]  
1
  • ISSUniProtKB
Histone deacetylase activitydefinition[GO:0004407]  
1
  • IDAMGI
Histone deacetylase bindingdefinition[GO:0042826]  
1
  • IPIUniProtKB
Hsp90 protein bindingdefinition[GO:0051879]  
1
  • IDABHF-UCL
Microtubule bindingdefinition[GO:0008017]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
NAD-dependent histone deacetylase activity (H3-K14 specific)definition[GO:0032041]  
  • IEAEC 2 GO
NAD-dependent histone deacetylase activity (H3-K18 specific)definition[GO:0097372]  
  • IEAEC 2 GO
NAD-dependent histone deacetylase activity (H3-K9 specific)definition[GO:0046969]  
  • IEAEC 2 GO
NAD-dependent histone deacetylase activity (H4-K16 specific)definition[GO:0046970]  
  • IEAEC 2 GO
Polyubiquitin bindingdefinition[GO:0031593]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
12
  • IPIIntAct
  • IPIUniProtKB
Tau protein bindingdefinition[GO:0048156]  
1
  • IDABHF-UCL
Tubulin deacetylase activitydefinition[GO:0042903]  
2
  • IDABHF-UCL
  • IDAUniProtKB
  • ISSOrtholog Curator
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Aggresome assemblydefinition[GO:0070842]  
1
  • IMPBHF-UCL
Cellular response to hydrogen peroxidedefinition[GO:0070301]  
1
  • IMPBHF-UCL
Cellular response to misfolded proteindefinition[GO:0071218] silver  
  • IEAOrtholog Compara
Cellular response to topologically incorrect proteindefinition[GO:0035967]  
1
  • IMPBHF-UCL
Histone deacetylationdefinition[GO:0016575]  
2
  • ISSUniProtKB
  • IDABHF-UCL
Histone H3 deacetylationdefinition[GO:0070932]  
  • IEAEC 2 GO
Histone H4 deacetylationdefinition[GO:0070933]  
  • IEAEC 2 GO
Hsp90 deacetylationdefinition[GO:0070846]  
1
  • IMPBHF-UCL
Intracellular protein transportdefinition[GO:0006886]  
1
  • IMPBHF-UCL
Lysosome localizationdefinition[GO:0032418]  
1
  • IMPBHF-UCL
Macroautophagydefinition[GO:0016236]  
1
  • IMPBHF-UCL
Misfolded or incompletely synthesized protein catabolic processdefinition[GO:0006515]  
1
  • IMPBHF-UCL
Negative regulation of hydrogen peroxide metabolic processdefinition[GO:0010727]  
1
  • ICBHF-UCL
Negative regulation of microtubule depolymerizationdefinition[GO:0007026] silver  
  • IEAOrtholog Compara
Negative regulation of oxidoreductase activitydefinition[GO:0051354]  
1
  • ICBHF-UCL
Negative regulation of protein complex disassemblydefinition[GO:0043242]  
1
  • IMPBHF-UCL
Negative regulation of proteolysisdefinition[GO:0045861]  
1
  • IMPBHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • ISSUniProtKB
Peptidyl-lysine deacetylationdefinition[GO:0034983]  
2
  • IMPBHF-UCL
Polyubiquitinated misfolded protein transportdefinition[GO:0070845]  
1
  • IMPBHF-UCL
Positive regulation of chaperone-mediated protein complex assemblydefinition[GO:0090035]  
1
  • IMPBHF-UCL
Positive regulation of epithelial cell migrationdefinition[GO:0010634]  
1
  • IMPBHF-UCL
Positive regulation of hydrogen peroxide-mediated programmed cell deathdefinition[GO:1901300]  
1
  • IDABHF-UCL
Positive regulation of receptor biosynthetic processdefinition[GO:0010870]  
2
  • IMPBHF-UCL
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • IMPBHF-UCL
Protein complex disassemblydefinition[GO:0043241] silver  
  • IEAOrtholog Compara
Protein deacetylationdefinition[GO:0006476]  
1
  • IMPBHF-UCL
Protein polyubiquitinationdefinition[GO:0000209] silver  
  • IEAOrtholog Compara
Regulation of androgen receptor signaling pathwaydefinition[GO:0060765]  
1
  • TASBHF-UCL
Regulation of establishment of protein localizationdefinition[GO:0070201] silver  
  • IEAOrtholog Compara
Regulation of microtubule-based movementdefinition[GO:0060632]  
1
  • ICBHF-UCL
Regulation of receptor activitydefinition[GO:0010469]  
1
  • IMPBHF-UCL
Response to growth factordefinition[GO:0070848]  
1
  • IMPBHF-UCL
Response to misfolded proteindefinition[GO:0051788]  
1
  • IMPBHF-UCL
Response to organic substancedefinition[GO:0010033]  
1
  • IMPBHF-UCL
Response to toxic substancedefinition[GO:0009636]  
1
  • IMPBHF-UCL
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Tubulin deacetylationdefinition[GO:0090042]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwaydefinition[GO:0043162] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.1.98: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 3 zinc ions per subunit.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
HSF1 activation  REACT_200744  
NOTCH1 Intracellular Domain Regulates Transcription  REACT_118780  
 

Keywords

Biological process 
Autophagy  definition   [KW-0072]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Hydrolase  definition   [KW-0378]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9UBN7
Other
GeneWiki: HDAC6
GenomeRNAi: 10013
PRO: PR:Q9UBN7
Chemistry
GuidetoPHARMACOLOGY: 2618