HEY2 - Hairy/enhancer-of-split related with YRPW motif protein 2 - human protein (Function)
 
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HEY2 »  Hairy/enhancer-of-split related with YRPW motif protein 2
 
Protein also known as:  Hairy and enhancer of split-related protein 2 (HESR-2).
Gene name:  HEY2
Family name: HEY
Entry whose protein(s) existence is based on evidence at protein level
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1 44 1
GENE REF ISO

Function

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Overview 
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.  
5
  • UniProtKB
GO molecular function 
Histone deacetylase bindingdefinition[GO:0042826]  
1
  • BHF-UCL
Microsatellite bindingdefinition[GO:0035939]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein binding transcription factor activitydefinition[GO:0000988]  
1
  • UniProtKB
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • InterPro 2 GO
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • BHF-UCL
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activitydefinition[GO:0000983]  
1
  • Ortholog Curator
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • BHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
GO biological process 
Anterior/posterior axis specificationdefinition[GO:0009948] silver  
1
  • Ortholog Compara
Arterial endothelial cell differentiationdefinition[GO:0060842]  
1
  • Ortholog Curator
Ascending aorta morphogenesisdefinition[GO:0035910]  
1
  • Ortholog Curator
Atrial septum morphogenesisdefinition[GO:0060413]  
1
  • Ortholog Curator
Cardiac epithelial to mesenchymal transitiondefinition[GO:0060317]  
1
  • Ortholog Curator
Cardiac left ventricle morphogenesisdefinition[GO:0003214]  
1
  • Ortholog Curator
Cardiac muscle hypertrophy in response to stressdefinition[GO:0014898] silver  
1
  • Ortholog Compara
Cardiac right ventricle morphogenesisdefinition[GO:0003215]  
1
  • Ortholog Curator
Cardiac septum morphogenesisdefinition[GO:0060411]  
1
  • Ortholog Curator
Cardiac vascular smooth muscle cell developmentdefinition[GO:0060948] silver  
1
  • Ortholog Compara
Cardiac ventricle morphogenesisdefinition[GO:0003208]  
1
  • Ortholog Curator
Cell fate commitmentdefinition[GO:0045165] silver  
1
  • Ortholog Compara
Cochlea developmentdefinition[GO:0090102] silver  
1
  • Ortholog Compara
Coronary vasculature morphogenesisdefinition[GO:0060977] silver  
1
  • Ortholog Compara
Dorsal aorta morphogenesisdefinition[GO:0035912]  
1
  • Ortholog Curator
Endocardial cushion to mesenchymal transition involved in heart valve formationdefinition[GO:0003199] silver  
1
  • Ortholog Compara
Heart trabecula formationdefinition[GO:0060347] silver  
1
  • Ortholog Compara
Labyrinthine layer blood vessel developmentdefinition[GO:0060716]  
1
  • Ortholog Curator
Mesenchymal cell developmentdefinition[GO:0014031]  
1
  • Ortholog Curator
Muscular septum morphogenesisdefinition[GO:0003150]  
1
  • Ortholog Curator
Negative regulation of cardiac muscle cell apoptotic processdefinition[GO:0010667] silver  
1
  • Ortholog Compara
Negative regulation of cardiac vascular smooth muscle cell differentiationdefinition[GO:2000723]  
1
  • Ortholog Curator
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • Ortholog Curator
Negative regulation of Notch signaling pathwaydefinition[GO:0045746] silver  
1
  • Ortholog Compara
Negative regulation of transcription by transcription factor localizationdefinition[GO:0010621]  
1
  • Ortholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
6
  • UniProtKB
  • BHF-UCL
Negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiationdefinition[GO:2000820]  
1
  • Ortholog Curator
Negative regulation of transcription initiation from RNA polymerase II promoterdefinition[GO:0060633]  
1
  • BHF-UCL
Negative regulation of transcription regulatory region DNA bindingdefinition[GO:2000678]  
1
  • BHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
2
  • UniProtKB
  • BHF-UCL
Notch signaling involved in heart developmentdefinition[GO:0061314]  
1
  • BHF-UCL
Notch signaling pathwaydefinition[GO:0007219]  
1
  • Ortholog Curator
Outflow tract morphogenesisdefinition[GO:0003151]  
1
  • Ortholog Curator
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045] silver  
1
  • Ortholog Compara
Positive regulation of heart ratedefinition[GO:0010460] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • Ortholog Curator
Protein-DNA complex assemblydefinition[GO:0065004] silver  
1
  • Ortholog Compara
Pulmonary artery morphogenesisdefinition[GO:0061156]  
1
  • Ortholog Curator
Pulmonary valve morphogenesisdefinition[GO:0003184]  
1
  • Ortholog Curator
Regulation of auditory receptor cell differentiationdefinition[GO:0045607] silver  
1
  • Ortholog Compara
Regulation of vasculogenesisdefinition[GO:2001212]  
1
  • Ortholog Curator
Smooth muscle cell differentiationdefinition[GO:0051145]  
1
  • BHF-UCL
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
Tricuspid valve formationdefinition[GO:0003195] silver  
1
  • Ortholog Compara
Tricuspid valve morphogenesisdefinition[GO:0003186]  
1
  • Ortholog Curator
Umbilical cord morphogenesisdefinition[GO:0036304]  
1
  • Ortholog Curator
Vascular smooth muscle cell developmentdefinition[GO:0097084]  
1
  • UniProtKB
Vasculogenesisdefinition[GO:0001570]  
1
  • Ortholog Curator
Ventricular cardiac muscle cell developmentdefinition[GO:0055015]  
1
  • Ortholog Curator
Ventricular septum morphogenesisdefinition[GO:0060412]  
1
  • Ortholog Curator
Ventricular trabecula myocardium morphogenesisdefinition[GO:0003222] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
NOTCH1 Intracellular Domain Regulates Transcription  REACT_118780  
 

Keywords

Biological process 
Notch signaling pathway  definition   [KW-0914]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: HEY2
GenomeRNAi: 23493
PRO: PR:Q9UBP5