EXTL2 - Exostosin-like 2 - human protein (Function)
 
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Protein
Gene
References

 
EXTL2 »  Exostosin-like 2   [ EC 2.4.1.223 ]
 
Protein also known as:  Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase. Cleaved into:  Processed exostosin-like 2.
Gene name:  EXTL2
Family name: Glycosyltransferase 47
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.  
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  • CuratedUniProtKB
GO molecular function 
Alpha-1,4-N-acetylgalactosaminyltransferase activitydefinition[GO:0035248]  
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  • IDAUniProtKB
Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activitydefinition[GO:0001888]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
Heparan sulfate proteoglycan biosynthetic processdefinition[GO:0015012]  
  • IEAUniPathway
N-acetylglucosamine metabolic processdefinition[GO:0006044]  
1
  • IDAUniProtKB
UDP-N-acetylgalactosamine metabolic processdefinition[GO:0019276]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.223: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 64  GT64  
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosaminoglycan biosynthesis - heparan sulfate  hsa00534+2135  
Metabolic pathways  hsa01100+2135  
 
More information is available from:
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EXTL2
GenomeRNAi: 2135
PRO: PR:Q9UBQ6