GRHPR - Glyoxylate reductase/hydroxypyruvate reductase - human protein (Function)
 
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GRHPR »  Glyoxylate reductase/hydroxypyruvate reductase   [ EC 1.1.1.81EC 1.1.1.79 ]
 
Gene name:  GRHPR
Entry whose protein(s) existence is based on evidence at protein level
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1 27 1
GENE REF ISO

Function

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Overview 
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.  
  • CuratedUniProtKB
GO molecular function 
Carboxylic acid bindingdefinition[GO:0031406] silver  
  • IEAOrtholog Compara
Glycerate dehydrogenase activitydefinition[GO:0008465]  
1
  • IDAUniProtKB
Glyoxylate reductase (NADP) activitydefinition[GO:0030267]  
2
  • IDAUniProtKB
Hydroxypyruvate reductase activitydefinition[GO:0016618]  
2
  • IDAUniProtKB
NAD bindingdefinition[GO:0051287]  
1
  • TASUniProtKB
NADPH bindingdefinition[GO:0070402]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
GO biological process 
Dicarboxylic acid metabolic processdefinition[GO:0043648] silver  
  • IEAOrtholog Compara
Excretiondefinition[GO:0007588]  
1
  • IMPUniProtKB
Metabolic processdefinition[GO:0008152]  
1
  • NASUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Protein oligomerizationdefinition[GO:0051259]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 1.1.1.79: Glycolate + NADP(+) glyoxylate + NADPH.  
  • CuratedUniProtKB
EC 1.1.1.81: D-glycerate + NAD(P)(+) hydroxypyruvate + NAD(P)H.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glyoxylate and dicarboxylate metabolism  hsa00630+9380  
Metabolic pathways  hsa01100+9380  
Pyruvate metabolism  hsa00620+9380  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q9UBQ7
Other
GeneWiki: GRHPR
GenomeRNAi: 9380
PRO: PR:Q9UBQ7