CTSZ - Cathepsin Z - human protein (Function)
 
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CTSZ »  Cathepsin Z   [ EC 3.4.18.1 ]
 
Protein also known as:  Cathepsin X.
Gene name:  CTSZ
Family name: Peptidase C1
Entry whose protein(s) existence is based on evidence at protein level
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1 29 1
GENE REF ISO

Function

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Overview 
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.  
  • CuratedUniProtKB
GO molecular function 
Cysteine-type peptidase activitydefinition[GO:0008234]  
  • IEAUniProtKB KW
GO biological process 
Epithelial tube branching involved in lung morphogenesisdefinition[GO:0060441] silver  
  • IEAOrtholog Compara
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.18.1: Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Lysosome  hsa04142+1522  
According to Reactome, this protein belongs to the following pathways:
Lysosome Vesicle Biogenesis  REACT_19287  
Metabolism of Angiotensinogen to Angiotensins  REACT_147707  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Cathepsin_Z
GenomeRNAi: 1522
PRO: PR:Q9UBR2