RPS6KB2 - Ribosomal protein S6 kinase beta-2 - human protein (Function)
 
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RPS6KB2 »  Ribosomal protein S6 kinase beta-2   [ EC 2.7.11.1 ]  (S6K2)
 
Protein also known as:  70 kDa ribosomal protein S6 kinase 2 (P70S6K2).
Gene name:  RPS6KB2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Phosphorylates specifically ribosomal protein S6.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Peptide bindingdefinition[GO:0042277] silver  
  • IEAOrtholog Compara
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • TASPINC
Ribosomal protein S6 kinase activitydefinition[GO:0004711] silver  
  • IEAOrtholog Compara
GO biological process 
Positive regulation of translational initiationdefinition[GO:0045948]  
1
  • IMPUniProtKB
Protein kinase B signalingdefinition[GO:0043491] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Translationdefinition[GO:0006412]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+6199  
ErbB signaling pathway  hsa04012+6199  
Fc gamma R-mediated phagocytosis  hsa04666+6199  
Insulin signaling pathway  hsa04910+6199  
mTOR signaling pathway  hsa04150+6199  
TGF-beta signaling pathway  hsa04350+6199  
According to Reactome, this protein belongs to the following pathways:
AKT phosphorylates targets in the nucleus  REACT_12442  
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: RPS6KB2
GenomeRNAi: 6199
PRO: PR:Q9UBS0
Chemistry
GuidetoPHARMACOLOGY: 1526