NXF1 - Nuclear RNA export factor 1 - human protein (Function)
 
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Protein
Gene
References

 
NXF1 »  Nuclear RNA export factor 1
 
Protein also known as:  Tip-associating protein.
Gene name:  NXF1
Family name: NXF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.  
4
  • UniProtKB
According to TCDB this is a transporter from family:
the nuclear mrna exporter (mrna-e) family  3.A.18.1.1  
GO molecular function 
Nucleotide bindingdefinition[GO:0000166] silver  
1
  • InterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
17
  • UniProtKB
  • IntAct
Single-stranded RNA bindingdefinition[GO:0003727]  
1
  • UniProtKB
GO biological process 
mRNA export from nucleusdefinition[GO:0006406]  
1
  • UniProtKB
Poly(A)+ mRNA export from nucleusdefinition[GO:0016973]  
1
  • RefGenome
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Herpes simplex infection  hsa05168+10482  
Influenza A  hsa05164+10482  
mRNA surveillance pathway  hsa03015+10482  
Ribosome biogenesis in eukaryotes  hsa03008+10482  
RNA transport  hsa03013+10482  
According to Reactome, this protein belongs to the following pathways:
Transport of Mature mRNA derived from an Intron-Containing Transcript  R-HSA-159236  
Transport of Mature mRNA Derived from an Intronless Transcript  R-HSA-159231  
Transport of the SLBP Dependant Mature mRNA  R-HSA-159230  
Transport of the SLBP independent Mature mRNA  R-HSA-159227  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transport  definition   [KW-0813]
mRNA transport  definition   [KW-0509]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NXF1
GenomeRNAi: 10482
PRO: PR:Q9UBU9