NXF1 - Nuclear RNA export factor 1 - human protein (Function)
 
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Protein
Gene
References

 
NXF1 »  Nuclear RNA export factor 1
 
Protein also known as:  Tip-associating protein.
Gene name:  NXF1
Family name: NXF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 77 2
GENE REF ISO

Function

 show evidences
Overview 
Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.  
3
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the nuclear mrna exporter (mrna-e) family  3.A.18.1.1  
GO molecular function 
mRNA bindingdefinition[GO:0003729] silver  
  • IEAOrtholog Compara
Nucleocytoplasmic transporter activitydefinition[GO:0005487] silver  
  • IEAOrtholog Compara
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
13
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
mRNA export from nucleusdefinition[GO:0006406]  
1
  • IDAUniProtKB
Poly(A)+ mRNA export from nucleusdefinition[GO:0016973] silver  
  • IEAOrtholog Compara
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Herpes simplex infection  hsa05168+10482  
Influenza A  hsa05164+10482  
mRNA surveillance pathway  hsa03015+10482  
Ribosome biogenesis in eukaryotes  hsa03008+10482  
RNA transport  hsa03013+10482  
According to Reactome, this protein belongs to the following pathways:
Gene Expression  REACT_71  
mRNA Processing  REACT_1675  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transport  definition   [KW-0813]
mRNA transport  definition   [KW-0509]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NXF1
GenomeRNAi: 10482
PRO: PR:Q9UBU9