B4GALT7 - Beta-1,4-galactosyltransferase 7 - human protein (Function)
 
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Protein
Gene
References

 
B4GALT7 »  Beta-1,4-galactosyltransferase 7   [ EC 2.4.1.- ]  (b4Gal-T7)
 
Protein also known as:  UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7.
Gene name:  B4GALT7
Family name: Glycosyltransferase 7
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

 show evidences
Overview 
Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.  
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  • CuratedUniProtKB
GO molecular function 
Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activitydefinition[GO:0003831]  
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  • IDAUniProtKB
Galactosyltransferase activitydefinition[GO:0008378]  
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  • IMPUniProtKB
Manganese ion bindingdefinition[GO:0030145]  
1
  • IDAUniProtKB
Xylosylprotein 4-beta-galactosyltransferase activitydefinition[GO:0046525]  
1
  • IDAUniProtKB
GO biological process 
Cellular protein modification processdefinition[GO:0006464]  
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  • TASPINC
Extracellular fibril organizationdefinition[GO:0043206]  
1
  • IMPUniProtKB
Glycosaminoglycan biosynthetic processdefinition[GO:0006024]  
1
  • IDAUniProtKB
Negative regulation of fibroblast proliferationdefinition[GO:0048147]  
1
  • IMPUniProtKB
Protein N-linked glycosylationdefinition[GO:0006487]  
1
  • IDAUniProtKB
Proteoglycan metabolic processdefinition[GO:0006029]  
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  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.133: UDP-alpha-D-galactose + O-beta-D-xylosyl-[protein] UDP + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein].  
1
  • CuratedUniProtKB
It requires the following cofactor
Manganese.  
1
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 7  GT7  
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycosaminoglycan biosynthesis - chondroitin sulfate  hsa00532+11285  
Glycosaminoglycan biosynthesis - heparan sulfate  hsa00534+11285  
Metabolic pathways  hsa01100+11285  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: B4GALT7
GenomeRNAi: 11285
PRO: PR:Q9UBV7